The usual bike 2.5 mile bike sprint with the offloader brace. A good effort, a few seconds slower than my last one.
2.5 mile mountain bike sprint - Laurel Branch Trl
Time - 10:04
Avg speed - 13.4 mphMax HR - 170
Avg HR - 162 (inc 1 min recovery at end)
HR over 156 - 9:29
HR over 170 - 0:40
Felt a bit harder than it probably should have. My previous was 10 sec faster with higher HR. I stood up to climb most of the short hills.
Started the day with 22 pull ups. Did a 15x slant board squats after the workout and some step downs.
Test results showed improved lipids, not optimal but improved. HDL is too low (35), Triglycerides too high (157), but a big 40 pt reduction in total cholesterol to 177, LDL from 147 to 115. No folate or B12 deficiencies measured. Marginal kidney function and the worst result was an increase in homocysteine to 18.6. Possible remedies for this are B6 and B complex vitamin supplementation and eliminating coffee and black tea. Need to test for B6 deficiency and possible thyroid cause.
Otherwise, relatively healthy, 141 lbs.
Just got cleared to perform a concert in the big cathedral Oct 19, and MTSU next day. Possibly the Villages on the 10th. Practicing a lot. School starts next week and I'm performing for the Convocation, which is a big deal.
For the unscientific cohorts who refuse to take statins whose main side effect is a longer life B vitamins have been trialed with no reduction and in one case worse outcomes for
ReplyDeleteInfarctions. All this worry and testing unnecessary if just go on statins. And the longer you wait the less the benefit. The unscientific type wait “until there is a proven problem” the scientific type takes it to prevent the problem.
Stop being a hypocrite.
NORVIT (Bønaa KH, et al. NEJM 2006) — post-MI patients
https://www.nejm.org/doi/full/10.1056/NEJMoa055227
Tested B-vitamin combinations in patients with a recent (<7 day) heart attack. Lowering homocysteine by up to 28% produced no reduction in MI or stroke risk — and the combination B-vitamin arm actually showed a trend toward increased cardiovascular risk, with folic acid alone also raising a signal for increased cancer risk. 
VISP (Toole JF, et al. JAMA 2004) — stroke patients
https://pubmed.ncbi.nlm.nih.gov/14762035/
Compared high-dose vs. low-dose B-vitamins in recent ischemic stroke patients. It found no benefit for preventing recurrent stroke, MI, or death — though this trial had design issues (described in doc 29) that complicated interpretation, including a subgroup with impaired kidney function that muddied the “normal renal function” comparison somewhat.
Bottom line across all three: despite consistently lowering homocysteine substantially, none showed the hoped-for reduction in heart attacks; HOPE-2 was the outlier with a modest stroke benefit, while NORVIT raised a possible harm signal. This is why homocysteine is now generally regarded as a marker rather than a proven causal, modifiable target — a pattern that held in both normal-kidney-function populations and the CKD trials discussed earlier.
Ask Claude this question: What is the lifespan benefit of stains in low to moderate risk patients over age 65. See what you come up with.
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