Another study. Another possible risk factor indicator: Triglyceride/HDL ratio. Here is the study issue paraphrased:
Low-density lipoprotein cholesterol (LDL-C) has been cited as the main responsible factor in CVD. Nonetheless, even when LDL-C is well regulated, mainly with statin therapy, a residual risk for CVD still occurs, and it is attributable to other lipid components, namely triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C). Increased TG and decreased HDL-C levels have been associated with metabolic syndrome (MetS) and CVD, and their ratio, TG/HDL-C, has been proposed as a novel biomarker for predicting the risk of both clinical entities... Inflammation plays a crucial role in the pathogenesis of cardiovascular disease (CVD), as it has been linked with both the initiation and progression of atherosclerosis. HDL-C has been linked to cardioprotective effects via its antioxidant and anti-inflammatory properties.
The above paper cites numerous studies showing the relationship between the TriG/HDL ratio and CVD.
Looking back at my previous test results, when my LDL reached it's highest, 203 (on the egg diet in '21), my HDL also reached it's highest, 59, while my TriG were low, 73. That gave me a TriG/ HDL ratio of 1.24. Best it had ever been. Then 4 months later, I congratulated myself for lowering my LDL to 105. But, my TriG/HDL ratio actually increased quite a lot: 117/44 = 2.70. Not terrible, but significantly worse.
As I had discussed in a previous post, the other metric that serves as a prognosticator for both CVD and stroke is the apolipoprotein B1/A ratio discussed in detail in this study.
Good paper. But of all the lipid parameters tri’s move around the most - my question for you would be did you have an extended fast or conform to the 7 to 10 hr? If you did a 24 hr fast your data will be biased low and the ranges of risk will probably be different. Here is a study on variability of various parameters. https://scholar.google.com/scholar?as_ylo=2021&q=diurnal+triglycerides+variation&hl=en&as_sdt=0,13#d=gs_qabs&t=1736682716791&u=%23p%3DCiRSAzFmcsQJ
ReplyDeleteSo this last lipid panel on low dose Lipitor I was 1.1 previous was 2.2.
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